余海中

发布者：gjqcadmin发布时间：2023-08-26浏览次数：

一、个人简介

余海中，安徽铜陵人，博士，讲师，中国生物化学与分子生物学学会和国际“柑橘黄龙病和韧皮部细菌病害系统学会（ISCHLP）”会员。2018年博士毕业后进入赣南师范大学生命科学学院工作，目前主要围绕柑橘病虫害的防控开展相关研究，已在International Journal of Biological Macromolecules、Journal of Agricultural and Food Chemistry和Insect Science等国际学术刊物上发表SCI论文36篇（单篇最高引用65次），《Archives of Insect Biochemistry and Physiology》、《Journal of Insect Science》、《Insect Molecular Biology》和《Arthropod-Plant Interactions》等杂志特邀审稿人，并担任Frontiers in Insect Science杂志Review editor（2021年-至今）。

E-mail：yuhaizhong1988@163.com

热忱欢迎园艺学相关专业同学报考本课题组研究生。

二、受教育经历

2015年9月—2018年7月，安徽农业大学，生物化学与分子生物学，理学博士

2012年9月—2015年7月，安徽农业大学，特种经济动物饲养，农学硕士

三、研究兴趣

1.柑橘黄龙病菌与柑橘木虱互作；

2.柑橘木虱生长发育关键基因的挖掘和功能研究；

3.小分子药物筛选以及对柑橘木虱的毒理机制。

四、主持和参与的科研项目

1.CLas病菌调控柑橘木虱骨架蛋白泛素化促进病菌转运机制研究，赣鄱俊才支持计划-主要学科技术和技术带头人培养青年人才项目，2024.01-2026.12，30万，主持

2.江西省自然科学基金面上项目，20224BAB205012，柑橘木虱泛素结合酶UbcE2J2调控骨架蛋白MRLC2促进CLas病菌转运机制研究，2023-01—2025.12，10万，主持；

3.国家自然科学基金地区项目，32260674，黄龙病菌分泌蛋白LepB介导柑橘木虱骨架蛋白的泛素化促进病菌转运机制研究，2023.01—2026.12，33万，主持；

4.国家重点研发计划（子课题），2021YFD1400800，柑橘黄龙病灾变机制与可持续防控技术研究，2021.12—2024.12，95万，主持；

5.江西省科技厅青年项目，20202BAB215004，柑橘木虱海藻糖酶基因的鉴定和生物学功能研究，2020.01—2022.12，6万，主持；

6.江西省教育厅重点项目，GJJ180747，Toll信号通路介导的组织蛋白酶L和O在柑橘木虱先天性免疫中的分子机制，2019.01—2020.12，5万，主持；

7.赣州市科技创新人才项目，柑橘木虱几丁质合成途径中海藻糖抑制剂的筛选及其在木虱防控中的应用，2020.01—2022.12，主持；

8.国家自然科学基金面上项目，32272549，柑橘黄龙病菌SDEs介导柑橘木虱中肠上皮细胞囊泡转运机制研究，2023.01—2026.12，54万，第二参与人；

9.国家自然科学基金地区项目，31960116，CLas病菌侵染柑橘木虱中肠及其调控UPS免疫逃避机制研究，2020.01—2023.12，40万，第二参与人；

10.国家自然科学基金面上项目，31472148，BmNPV与宿主家蚕中肠及胞内蛋白互作的分子机制研究，2014.01—2018.12，80万，第三参与人。

  1. 近年来部分科研成果

主要论文（*：通讯作者；#：共同一作）：

  1. Wei Chen, Muhammad Bilal Amir, Yuan Liao,Hai-Zhong Yu, Wei-Yi He *, Zhan-Jun Lu *. New Insights into thePlutella xylostella Detoxifying Enzymes: Sequence Evolution, Structural Similarity, Functional Diversity, and Application Prospects of Glucosinolate Sulfatases. Journal of Agricultural and Food Chemistry, 2023, accepted. (中科院大类1区top, IF: 6.1)

  2. Tao Xia, Yan Liu, Zhan-Jun Lu,Hai-Zhong Yu *. Natural Coumarin Shows Toxicity toSpodoptera litura by Inhibiting Detoxification Enzymes and Glycometabolism. International Journal of Molecular Sciences, 2023, 24, 13177 (中科院大类2区top, IF: 5.6).

  3. Qin Zhang, Tao Xia, Ai-Yun Wang, Yan Liu, Ning-Yan Li, Long Yi, Zhan-Jun Lu,Hai-Zhong Yu *. Alternative splicing of chitin deacetylase 2 regulates chitin and fatty acid metabolism in Asian citrus psyllid,Diaphorina citri. Archives of Insect Biochemistry and Physiology, 2023, accepted. (中科院大类4区, IF: 2.2).

  4. Xiu-Dao Yu, Hollie Marshall, Yan Liu, Yu Xiong, Xiang-Dong Zeng,Hai-Zhong Yu, Wei Chen, Gu-Chun Zhou, Bo Zhu, Laura Ross, Zhan-Jun Lu. Sex-specific transcription and DNA methylation landscapes of the Asian citrus psyllid, a vector of huanglongbing pathogens. Evolution, 2023, (中科院大类2区top, IF: 4.171).

  5. Jin-Bo Zhang, Xiao-Jin Zou, Qin Zhang, Ai-Yun Wang, Muhammad Bial Amir, Yi-Min Du, Xiao-Qiang, Liu, Wei Chen, Zhan-Jun Lu,Hai-Zhong Yu *. Quantitative ubiquitylome crosstalk with proteome analysis revealed cytoskeleton proteins influenceCLas pathogen infection inDiaphorina citri. International Journal of Biological Macromolecules, 2023, 232, 123411 (中科院大类1区top, IF: 8.025).

  6. Jin-Bo Zhang, Zhan-Jun Lu,Hai-Zhong Yu *, Silencing of Glycogen Synthase Kinase 3 Significantly Inhibit Chitin and Fatty Acid Metabolism in Asian Citrus Psyllid,Diaphorina citri. International Journal of Molecular Sciences, 2022, 23, 9654 (中科院大类2区top,IF: 6.208).

  7. Ying-Xue Liu, Lin-Bao Zhu, Zhe-Xiao Guo, Han-Dan Zhu, Zhi-Hao Huang, Hui-Hua Cao,Hai-Zhong Yu, Shi-Huo Liu, Jia-Ping Xu,Bombyx mori ferritin heavy-chain homolog facilitates BmNPV proliferation by inhibiting reactive oxygen species-mediated apoptosis. International Journal of Biological Macromolecules, 2022, 217, 842-852 (中科院大类1区top, IF: 8.025).

  8. Hai-Zhong Yu, Long Yi *, Zhan-Jun Lu *, Silencing of chitin-binding protein with PYPV-rich domain impairs cuticle and wing development in the Asian citrus psyllid,Diaphorina citri. Insects, 2022, 13, 353 (中科院大类2区, IF: 3.139).

  9. Ying Wang, Qin Zhang,Hai-Zhong Yu*, Functional analysis of a peptidoglycan recognition protein involved in the immune response in the common cutworm,Spodoptera litura. Archives of Insect Biochemistry and Physiology, 2022, 109, e21858 (中科院大类4区, IF: 2.454).

  10. Jian-Chun Song, Zhan-Jun Lu, Long Yi *,Hai-Zhong Yu*, Physiological functions of a novel trehalose-6-phosphate synthase inDiaphorina citri revealed that by RNA interference and transcriptome. Insects, 2021, 12, 1074 (中科院大类2区, IF: 3.139).

  11. Xiao-Qiang Liu, Hong-Bo Jiang, Jia-Yao Fan, Tian-Yuan Liu, Li-Wei Meng, Yi Liu,Hai-Zhong Yu, Wei Dou, Jin-Jun Wang. An odorant-binding protein of Asian citrus psyllid,Diaphorina citri, participates in the response of host plant volatiles. Pest Management Science, 2021, 77, 3068-3079. (中科院大类1区top, IF: 4.462).

  12. Hai-Zhong Yu#, Qin Zhang#, Zhan-Jun Zhang*, Ming-Jie Deng*. Validamycin treatment significantly inhibits the glycometabolism and chitin synthesis in the common cutworm,Spodoptera litura. Insect Science, 2022, 29, 840-854. (中科院1区top, IF: 3.605)。

  13. Hai-Zhong Yu#, Yan-Xin Xie#, Jie Wang, et al. Integrated transcriptome sequencing and RNA interference reveals the molecular changes ofDiaphorina citri exposure to validamycin, Insect Science, 2021, 28, 1690-1707. (中科院1区top, IF: 3.605)

  14. Hai-Zhong Yu#, Yu-Ling Huang#, Zhan-Jun Lu*, et al. Inhibition of trehalase affects the trehalose and chitin metabolism pathways inDiaphorina citri (Hemiptera: Psyllid), Insect Science, 2021, 28, 718-734. (中科院1区top, IF: 3.605)

  15. Hai-Zhong Yu#, Ning-Yan Li#, Bing Li, et al. Immune functional analysis of chitin deacetylase 3 from the Asian citrus psyllidDiaphorina citri. International Journal of Molecular Sciences, 2020, 21, 64.

  16. Hai-Zhong Yu#, Ning-Yan Li#, Xiang-Dong Zeng, et al. Transcriptome analysis ofDiaphorina citri midgut responses toCandidatus Liberibacter asiaticus infection. Insects, 2020, 11, 171. (IF: 2.139)

  17. Hai-Zhong Yu#,Ning-Yan Li#, Yan-Xin Xie, et al. Identification and functional analysis of two chitin synthase genes in the common cutworm,Spodoptera litura, Insects, 2020, 11, 253.

  18. Hai-Zhong Yu, Yu-Ling Huang, Ning-Yan Li, et al. Potential roles of two Cathepsins genes,DcCath-L andDcCath-O in the innate immune response ofDiaphorina citri. Journal of Asia-Pacific Entomology, 2019, 22: 1060-1069.

  19. Hai-Zhong Yu, Jie Wang, Shang-Zhi Zhang, et al. Molecular characterization ofApolipophorin-Ⅲ gene inSamia cynthia riciniand its roles in response to bacterial infection. Journal of Invertebrate Pathology, 2018, 159, 6170.

  20. Hai-Zhong Yu, Yan Ma, Shang-Zhi Zhang, et al. Comparative transcriptome analysis of ATP-binding cassette (ABC) transporter genes in eri-silkworm,Samia cynthia riciniin response to 1-deoxynojirimycin, Journal of Asia-Pacific Entomology, 2018: 168-178.

  21. Hai-Zhong Yu, Xue-Yang Wang, Jia-Ping Xu*, et al. iTRAQ-based quantitative proteomics analysis of molecular mechanisms associated withBombyx mori (Lepidoptera) larval midgut response to BmNPV in susceptible and near-isogenic strains, Journal of Proteomics, 2017, 165, 35-50.

  22. Hai-Zhong Yu, Shang-Zhi Zhang, Yan Ma, et al. Molecular Characterization and Functional Analysis of a Ferritin Heavy Chain Subunit from the Eri-Silkworm,Samia cynthia ricini, International Journal of Molecular Sciences, 2017.

  23. Hai-Zhong Yu, Jia-Ping Yu*, Xue-Yang Wang, et al. Identification of four ATP-binding cassette transporter genes inCnaphorina medinalisand their expression in response to insecticide treatment, Journal of Insect Science, 2017, 17, 1-8.

  24. Hai-Zhong Yu, Ming-Hui Liu, Xue-Yang Wang, et al. Identification and expression profiles of chitin deacetylases genes in the rice leaf folder,Cnaphorina medinalis, Journal of Asia-Pacific Entomology, 2016, 19: 691-696.

  25. Hai-Zhong Yu, De-Fu Wen, Wan-Lin Wang, et al. Identification of genes putatively involved in Chitin Metabolism and Insecticide Detoxification in the rice leaf folder (Cnaphalocrocis medinalis) larvae through transcriptome analysis, International Journal of Molecular Sciences, 2015, 16, 21873-21896.

  26. Zhan-Jun Lu#, Yu-Ling Huang#,Hai-Zhong Yu*,et al. Silencing of the Chitin Synthase Gene Is Lethal to the Asian Citrus Psyllid,Diaphorina citri, International Journal of Molecular Sciences, 2019, 20, 3734.

  27. Zhan-Jun Lu#,Hai-Zhong Yu#,Lan-Fang Mi#, et al. The effects of inarching Citrus reticular Blanco var. tangerine on the tree vigor, nutrient status and fruit quality of Citrus sinensis Osbeck ‘Newhall’ trees that havePoncirus trifoliata (L.) Raf. as rootstocks. Scientia Horticulturae, 2019, 256, 108600.

  28. Zhan-Jun Lu#, Yan-Xin Xie#,Hai-Zhong Yu*, et al. Identification of an iron binding protein, ferritin heavy chain subunit and functional analysis, from swallowtail butterfly,Papilio xuthus. Archives of Insect Biochemistry & Physiology, 2019, 102, 1.

  29. Zhan-Jun Lu#, Cheng-Hua Zhou#,Hai-Zhong Yu*,et al. Potential roles of insect Tropomyosin1-X1 isoform in the process ofCandidatus Liberibacter asiaticus infection ofDiaphorina citri, Journal of Insect Physiology, 2019, 114, 125-135 (IF: 2.862).

  30. Dong-Qiong Fei#,Hai-Zhong Yu#, Jia-Ping Xu, et al. Isolation of ferritin and its interaction with BmNPV in the silkworm,Bombyx mori, Developmental and Comparative Immunology, 2018, 130-137.

  31. Bing Li#,Hai-Zhong Yu#, Chong-Jun Ye, et al.Bombyx mori Seripin6 regulates prophenoloxidase activity and the expression of antimicrobial proteins, Gene, 2017, 610, 64-70. (IF: 2.638).

  32. Xue-Yang Wang#,Hai-Zhong Yu#, Jia-Ping Xu*, et al. Comparative subcellular proteomics analysis of susceptible and near-isogenic resistantBombyx mori (Lepidoptera) larval midgut response to BmNPV infection, Scientific Reports, 2017, 7, 45690.

  33. Xue-Yang Wang#,Hai-Zhong Yu#, Lei Geng, et al. Comparative transcriptome analysis ofBombyx mori (Lepidoptera) larval midgut response to BmNPV in susceptible and near-isogenic resistant strains, PLoS One, 2016, 11, e0155341.

  34. Shang-Zhi Zhang#,Hai-Zhong Yu#, Ming-Jie Deng, et al. Comparative transcriptome analysis reveals significant metabolic alterations in eri-silkworm (Samia cynthia ricini) haemolymph in response to 1-deoxynojirimycin, PLoS One, 2018, 13, e0191080.

  35. Azharuddin, Muhammad, Shahzad, Toufeeq,Hai-Zhong Yu, et al. Molecular characterization of two mitogen-activated protein kinases: p38 MAP kinase and ribosomal S6 kinase fromBombyx mori (Lepidoptera: Bombycidae), and insight into their roles in response to BmNPV infection, Journal of Insect Science, 2019, 19, 15.

  36. Li-Ang Yang, Jie Wang, Shahzad, Toufeeq, Lin-Bao Zhu, Shang-Zhi Zhang, Ling-Ling You, Pei Hu,Hai-Zhong Yu, Kang Zhao, Jia-Ping Xu, Identification of FerLCH, isolation of ferritin and functional related to interaction with pathogens in Eri-silkworm,Samia cynthia ricini, Archives of Insect Biochemistry and Physiology, 2020, 104, e21659.

申报的专利：

  1. 发明人：余海中、张金波、方瑜婕、段硕、陈玮、卢占军、胡威、朱博、姚锋先、黄爱军、苏华楠、彭婷、欧阳智刚、舒佳旺、刘佳阳，发明专利名称：一种获得CLas侵染柑橘木虱虫体的方法；时间：2022.05.013；专利号：202210504089.X.

  2. 发明人：卢占军、曾祥东、张金波、余海中、方瑜婕、胡威、陈玮、黄爱军、彭婷、姚锋先、邹小金、谢廉颉、汪和贵、舒佳旺、刘淑婷，发明专利名称：柑橘木虱泛素结合酶E2J2基因在防控柑橘黄龙病中的应用；时间：2022.05.09；专利号：202210490662.6.

  3. 发明人：张金波，方瑜婕，余海中，汪和贵，刘淑婷，黄爱军，刘佳阳，赖子俊，卢占军，舒佳旺，曹鑫磊，曾祥东；实用新型专利名称：一种对照实验用刺吸式昆虫饲养装置；申请时间：2022.5.19；专利号：ZL202221218071.5.

  4. 发明人：卢占军，邹俊丞，钟八莲，饶敏，苏华楠，余海中，王年，乔宁，邝敏；发明专利名称：一种基于树皮韧皮部的脐橙黄龙病近红外检测模型建立方法；申请时间：2019.01.18；专利号：201811611126.7.

  5. 发明人：余海中，卢占军，谢妍馨，李宁艳，喻修道，黄爱军，易龙，苏华楠，钟八莲；发明专利名称：柑橘木虱几丁质结合蛋白Chitinase-like ENO3及其编码基因和应用；国际专利申请号：PCT/CN2020/100775；国际申请日：2020年7月8日；发文日：2021年4月9日。

六、指导学生情况

1. 2022年，指导2020级研究生张金波获得研究生国家奖学金；

2. 2022年，指导2022级本科生王雪妍获得华中昆虫学术会议研究生组报告三等奖；

3. 2022年，指导2022年全国大学生生命科学竞赛（科学探究类）江西赛区三等奖；

4. 2020年，指导2018级研究生李宁艳获得研究生国家奖学金；

5. 2019年，指导2018级研究生谢妍鑫获得江西省园艺学会奔象杯“优秀学术论文”一等奖。

6. 2019年，指导2017级研究生黄玉玲获得研究生国家奖学金；